Small interfering RNAs (siRNAs) and microRNAs (miRNAs) are sequence-specific post-transcriptional regulators of gene expression. Although major components of the RNA interference (RNAi) pathway have been identified, regulatory mechanisms for this pathway remain largely unknown. Here we demonstrate that the RNAi pathway can be modulated intracellularly by small molecules.
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By Doug Macron
A research team led by investigators from Emory University this week published data showing how a novel cell-based assay technology, licensed to startup Effigene Pharmaceuticals, was able to identify a small molecule that could enhance siRNA-mediated mRNA degradation and endogenous microRNA biogenesis. (more…)
A way to turn off one gene at a time has earned acceptance in biology laboratories over the last decade. Doctors envision the technique, called RNA interference, as a tool to treat a variety of diseases if it can be adapted to humans